The diagnostic signficance of thyroid peroxidase
- VernacularTitle:Анти-TPO, анти-Tg ауто-эсрэгбиеийн мэдээллэг чанар тодорхойлсон дүн
- Author:
Unurjargal Kh
;
Batbaatar G
;
Khadkhuu V
- Publication Type:Journal Article
- Keywords:
thyroid;
thyroid peroxidase antibody;
thyroglobulin antibody;
hyperthyrodism;
hypothyrodism
- From:
Health Laboratory
2013;1(1):11-14
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:
In our country the thyroid diseases usually diagnosed using only laboratory indicators of thyroid hormons such as T3, T4, TSH and medical symptom. It means there are considerably late diagnosing of thyroid failure. In recently hypothyroidism and hypothyroidism are being diagnosed by specific thyroid antibodies which are instead during thyroid disorders in the worldwide. Although this diagnostic method is used in some laboratory in our country but their diagnostic significance have not yet been determined. It is important to lunce diagnostic methods for thyroid antibodies specially essential for endocrine doctors.
Objective:
To determine the diagnostic significance of thyroglobulin antibody and thyroid peroxidase antibodies in relation with thyroid disease.
Research materials and methods:
In this research of thyroid peroxidase antybody and thyroglobulin antibody, we use 20-64 age 23 patients who have hypothyrodism diagnostics, 36 patients how have hyperhotyrodism diagnostics, 30 patients who are relatively healthy and their disease was denied on symptom and laboratory test, total 89 people.
Results:
There were 57 female and 32 male from total 89 people investigated for this study. The traditional determination of thyroid hormones for diagnosis of thyroid diseases still have high diagnostic significance. The newly launched and used in our study anti-TPO and anti-Tg have very high significance for thyroid diagnosis. We found that anti-TPO antibody has primary information indicator and anti-Tg antibody is secondary information indicator for the diagnosis of thyroid disorder.
Conclusion:
1.Among 59 patients with thyroid diseases 89.8% (n=53) of them determined increased anti-TPO concentration and 61% (n=36) of them increased anti-Tg concentration. It shows increase of these antibodies have high diagnostic significance for thyroid diseases.
2.For hyperthytiodism the anti-TPO has strong supportive information indicator (карра=0,64) and anti-Tg has primary information indicator (карра=0,84).
3.For hypothytiodism the anti-TPO has primary information indicator (карра=0,78) and anti-Tg has weak supportive information indicatot (карра=0,24).
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