ErbB4 Deletion Leads to Changes in Lung Function and Structure Similar to Bronchopulmonary Dysplasia
- VernacularTitle:ErbB4 Deletion Leads to Changes in Lung Function and Structure Similar to Bronchopulmonary Dysplasia
- Author:
ERKHEMBULGAN Purevdorj
- Publication Type:journal article
- From:Innovation
2008;5(1):26-26
- CountryMongolia
- Language:English
-
Abstract:
Neurcgulin is an important emwth faetor in fetal surfactant synthesis and down regulatie" "f its receptor hrbB4 impairs fetal surfactant synthesis. We hypothesized that pultnonary HrbB4 deletion will affect the developing lung leading to an abnormal postnatal lung function. ErbB4 deleted lungs of 11 tol4 weeks old adult HER4hoa" mice, rescued from their lethal cardiac defects, were studied for the effect on lung function, alvcolarization, and the surfactant system. ErbB4 deletion impairs lung function and structure in mice resulting in a hyperreactive airway system and alveolar
simplification, as seen in preterm infants with bronchopulmonary dysplasia. It also leads to a down regulation of surfactant protein D expression and an underlying chronic inflammation in these lungs. Our findings suggest that this animal model could be used to further study the pathogenesis of bronchopulmonary dysplasia and might help design protective interventions
