To study other biomarkers that assess during myocardial infarction
- VernacularTitle:Ийлдсийн ММР-9, oxLDL ба C урвалж уургийн түвшингээр титэм судасны хатуурлын хүндрэлийг үнэлэх нь
- Author:
Sumiya Ts
;
Odkhuu E
;
Tsogtsaikhan S
;
Zorigoo Sh
;
Munkhzol M
- Publication Type:Journal Article
- Keywords:
matrix metalloproteinase-9;
oxLDL;
CRP;
plaque rupture;
coronary angiography
- From:Mongolian Medical Sciences
2015;174(4):12-18
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background. When the coronary atherosclerotic plaque becomes vulnerable, a thrombus develops on
that ruptured plaque and then occludes the coronary artery, which causes an acute blood defi ciency in
the downstream myocardium.
Furthermore oxLDL (oxidized Low Density Lipoprotein) is involved in the coronary atherosclerotic plaque
pathogenesis, MMP-9 (Matrix Metalloproteinase-9) enzymes plays role during the plaque rupture and
CPR (C Reactive Protein) has a prognostic value in myocardial infarction.
Objective. To determine the involvement of oxLDL, MMP-9, CRP markers in the pathogenesis of
myocardial infarction, to study their involvement in the injury of the myocardium and to evaluate the
complications.
Material and Methods. The study was conducted using case-control design. The main inclusion criteria
of the 40 case groups are that the patient should have a ruptured coronary atherosclerotic plaque,
confi rmed by clinical symptom, ECG, serum troponin I, and coronary angiography. Also 40 patients with
coronary stenosis or chronic occlusion without ruptured plague were included in the control group.
Serum MMP-9 enzyme and oxLDL titers were determined by ELISA according to the manufacturer’s
recommended protocol. Additionally CRP was measured by full-automated analyzater. We used CIIS
(cardiac infarction injury score) by ECG and Gensini score system (Coronary Angiographic Scoring
System) for assessing the severity of coronary heart disease.
Results. Serum MMP-9, oxLDL levels (p<0.001) in the case group (ÌÌÐ-9 0.396±0.155 ng/ml; oxLDL
1.411±0.099 μg/ml) were more than in the control group (ÌÌÐ-9 0.223±0.087 ng/ml; oxLDL 1.332±0.163
μg/ml).
The logistic analysis shows that ÌÌÐ-9, oxLDL, CRP (MMP-9 OR=0.985, p<0.001; oxLDLOR=0.011,
p<0.05; CRP OR=0.041, p<0.005) may play a role in the pathogenesis of the plaque rupture.
Serum MMP-9 enzyme level was directly correlated with Gensini score (r=0.552, p<0.01), CIIS (r=0.340,
p<0.01) and CRP (r=0.321, p<0.01) titers.
Furthermore, serum MMP-9 enzyme increases with accordance of severity of the myocardium injury
with the statistical signifi cance (p<0.01): the borderline abnormality group (CIIS<10, 0.227±0.099 ng/
ml), possible injury (CIIS 10-15, 0.317±0.132 ng/ml), probable injury (CIIS >15, 0.376±0.132 ng/
ml) groups. MMP-9 levels were signifi cantly higher in the probable injury group patients (CIIS >15)
compared to the possible injury group patients (CIIS 10-15) (p<0.001).
ROC Curve analysis shows that MMP-9 enzyme levels variance (area=0.87, p<0.001) are more
than other biomarkers making it a diagnostically benefi cial for the coronary atherosclerotic plaque
rupture (CRP area=0,733, p<0.001, oxLDL area=0.635, p<0.05).
Conclusion: Serum MMP-9, oxLDL and CRP are signifi cantly involved in the pathogenesis of coronary
atherosclerotic plaque rupture in the myocardial infarction.
- Full text:P020170421650318068942.pdf
