The effect of bee venom on kidney function in alloxan induced diabetic rabbits
- VernacularTitle:Туулайд аллоксанаар үүсгэсэн ЧШӨ-ний үеийн бөөрний үйл ажиллагаанд зөгийн хорны үзүүлэх нөлөөг судалсан дүн
- Author:
Khulan Ts
;
Ambaga M
;
Chimedragchaa Ch
- Publication Type:Journal Article
- Keywords:
bee venom;
diabetes;
Alloxan;
kidney;
creatinine;
urea
- From:Mongolian Medical Sciences
2015;172(2):82-86
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background
Diabetes is a metabolic disorder that is characterized by chronic high blood glucose levels that causes
complications in the eyes, kidneys, heart, vessels and nerves. Currently diabetic nephropathy is the
most significant long-term complications in terms of morbidity and mortality for individual patients
with diabetes. Honey bee venom can be considered as a natural remedy for diabetes due to its blood glucose levels lowering and lipid-regulating effect on diabetic rabbits.
Aim
The aim of this study was to investigate the effect of Mongolian honey bee venom (Apis mellifera) on renal dysfunction in alloxan induced diabetic rabbits.
Material and Method
Twenty two Chinchilla rabbits were divided into three groups: control (n=6), diabetic (n=8), and bee venom treated (n=8). The diabetic group was injected with 5% solution of Alloxan monohydrate 100 mg/kg intravenously behind the ear for 2 minutes to induce diabetes. The bee venom treated group received a bee sting (a sting contains 0.2-0.5 ml of bee venom) on their hind paw every day after their diagnosis of diabetes.
Result
Bee venom treatment (BVT) led to the following changes: compared to the diabetic group, the bee venom treated group’s blood glucose levels lowered between 14.9% and 26.5%; the plasma creatinine and urea levels were decreased respectively by 19,8% and 14.8%. Blood urea nitrogen (BUN) levels were reduced by 14.8%.
Conclusion:
Treatment with Mongolian bee venom lowered the blood glucose levels and prevents the renal dysfunction in alloxan induced diabetic rabbits
- Full text:P020170421586228062157.pdf
