Chronic obstructive pulmonary disease: new information about pathogenetic mechanisms
- VernacularTitle:Уушгины архаг бөглөрөлт өвчний эмгэг жамын механизмын сүүлийн үеийн ойлголтууд
- Author:
Solongo Kh
;
Narantsetseg J
;
Odonchimeg B
;
Gombosuren B
;
Ambaga B
- Publication Type:Review
- Keywords:
chronic obstructive respiratory disease;
free-radical oxidation;
nitrogen oxide;
pulmonary hypertension;
chronic corpulmonale
- From:Mongolian Medical Sciences
2013;164(2):101-106
- CountryMongolia
- Language:Mongolian
-
Abstract:
The pathogenesis of chronic obstructive pulmonary disease (COPD) encompasses a number of injurious processes, including an abnormal inflammatory response in the lungs to inhaled particles and gases. Other processes, such as failure to resolve inflammation, abnormal cell repair, apoptosis, abnormal cellular maintenance programs, extracellular matrix destruction (protease/antiprotease imbalance), and oxidative stress (oxidant/antioxidant imbalance) also have a role. The inflammatory responses to the inhalation of active and passive tobacco smoke and urban and rural air pollution are modified by genetic and epigenetic factors. The subsequent chronic inflammatory responses lead to mucus hypersecretion, airway remodeling, and alveolar destruction. This article provides an update on the cellular and molecular mechanisms of these processes in the pathogenesis of COPD. During the past decade a plethora of studies have unravelled the multiple roles of nitric oxide (NO) in airway physiology and pathophysiology. In the respiratory tract, NO is produced by a wide variety of cell types and is generated via oxidation ofL-arginine that is catalyzed by the enzyme NO synthase (NOS). NOS exist in three distinct are forms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO derived from the constitutive are forms of NOS (nNOS and eNOS) and other NO-adduct molecules (nitrosothiols) have been shown to be modulators of bronchomotor tone. On the other hand, NO derived from iNOS seems to be a proinflammatory mediator with immunomodulatory effects. Finally, the production of NO under oxidative stress conditions secondarily generates strong oxidizing agents (reactive nitrogen species) that may modulate the development of chronic inflammatory airway diseases and/or amplify the inflammatory response.
- Full text:P020170422741992751016.pdf
