The situation of drug resistant bacterial infection in the intensive care unit of the first central state hospital, Mongolia
- VernacularTitle:Улсын нэгдүгээр төв эмнэлгийн эрчимт эмчилгээний тасагт тохиолдож буй антибиотикт тэсвэртэй нянгийн халдварын судалгаа
- Author:
Otgon Baatar
;
Erdembileg Batchuluun
;
Ganbold Lundeg
- Publication Type:Journal Article
- Keywords:
Sepsis;
antibiotic resistance;
extensively drug resistant;
multiple drug resistant;
pan drug resistant
- From:Mongolian Medical Sciences
2014;167(1):10-14
- CountryMongolia
- Language:Mongolian
-
Abstract:
INTRODUCTION:
Sepsis is always a serious, life-threatening condition, with high mortality rate varying from 30-50%
(40-70% in septic shock) in the developed countries, and in developing countries as well. Antibiotic
resistance is an important factor in sepsis management.
GOAL:
To evaluate the resistance patterns of microorganisms, to analyze the correlation between outcome
of sepsis patient and multidrug resistant bacterial infection.
MATERIALS AND METHODS:
This study was designed as a prospective observational study and conducted in a nine bed
multidisciplinary intensive care unit (ICU) of a tertiary teaching hospital in Ulaanbaatar, during January
2011 - August 2012. The ICU treatment outcome and length of stay were compared between the
patient groups which infected by resistant and non-resistant bacteria.
RESULTS:
The positive rate of extensively resistant (XDR) and multi drug resistant bacteria by culture test
were 22% and 25.1%, respectively. Fifty one percent of sepsis patients were infected by one or
more resistant bacteria. Bacteria with an exceptionally high rate of antibiotic resistance (≥60%) were
Acinetobacter baumannii, Enterobacter spp and coagulase-negative Staphylococci. Sepsis patients
who were infected with resistant bacteria received more mechanical ventilation, renal replacement
therapy and suffered from multiple organ dysfunctions when compared to sepsis patients with nonresistant
bacterial infection. The length of stay in the ICU was longer in sepsis patients with resistant
bacteria but the mortality rate in the ICU did not significantly differ between groups. However, a
higher fatality rate was noted in sepsis patients infected with resistant bacteria.
In conclusion, resistant bacteria were detected in up to 50% of microbiological samples from critically
ill sepsis patients in the ICU of a tertiary teaching hospital in Ulaanbaatar. Antibiotic resistance
appears to be a relevant problem of sepsis management in a Mongolian ICU setting.
- Full text:P020151216456868479847.pdf
