Acute necrotising encephalopathy of childhood: A review of two cases
- Author:
Sidney, Ching Liang Ong
;
Nur Azidawati Abdul Halim
;
Yuan Hwen, Liew
;
Anita Sahal
- Publication Type:Case report
- Keywords:
Gait disorders;
gastroenteritis;
mycoplasma infections;
Respiratory Syncytial Viruses;
seizures
- MeSH:
Brain Diseases;
Mycoplasma Infections
- From:
The Medical Journal of Malaysia
2017;72(5):311-313
- CountryMalaysia
- Language:English
-
Abstract:
Acute necrotising encephalopathy of childhood (ANEC) is
an uncommon disease with characteristic clinical and
imaging findings. We present two cases of ANEC secondary
to Respiratory Syncytial Virus (RSV) and mycoplasma
infections. An eight-month-old boy presented with features
of gastroenteritis but soon developed multiple episodes of
seizures. Blood and CSF cultures were negative but
nasopharyngeal aspirate immunofluorescence was positive
for RSV. A nine-year-old girl presented with abnormal
behaviour following two days of prodromal symptoms. Her
serological markers implicated mycoplasma (IgM titre 1:
640). CT brain of both patients showed bilateral symmetrical
thalamic hypodensities, while MRI revealed more extensive
white matter involvements.
