Determination of the 99th percentile upper reference limit for high-sensitivity cardiac troponin I in Malaysian population
- Author:
Say Min Lim
;
Subashini C Thambiah
;
Siti Yazmin Zahari Sham
;
Roslina Omar
;
Zarida Hambali
;
Intan Nureslyna Samsudin
- Publication Type:Original Article
- Keywords:
high-sensitivity;
troponin I;
99th percentile;
Malaysian;
gender
- From:The Malaysian Journal of Pathology
2017;39(2):135-140
- CountryMalaysia
- Language:English
-
Abstract:
Introduction of high-sensitivity cardiac troponin I (hscTn I) assays for routine clinical use in
Malaysia requires determination of the 99th percentile upper reference limit (URL) for each assay to
suit local context. Hence, this study aimed to determine the 99th percentile URL for hscTn I in the
Malaysian population. A total of 250 (120 males and 130 females) healthy Malaysian blood donors
aged 18 to 60 years old were recruited. Blood samples for hscTn I were measured using Abbott
Diagnostics hscTn I assay on Architect i2000sr analyser. The 99th percentile was calculated using
a non-parametric method and gender specific results were compared. The 99th percentile URL for
hscTn I for the overall population was 23.7 ng/L, with gender specific values being 29.9 ng/L and
18.6 ng/L for male and female, respectively. Females had significantly lower hscTn I compared to
males. This study confirms the use of gender specific 99th percentile URL for hscTn I for clinical
use in a multi-ethnic Malaysian population.
