Anti-M induced severe haemolytic disease of foetus and newborn in a Malay woman with recurrent pregnancy loss
- Author:
Mohd Nazri Hassan Mpath
;
Noor Haslina Mohd Noor Mpath
;
Shafini Mohammed Yusoff Mpath
;
Noor Shaidatul Akmal Ab Rahman
;
Rapiaah Mustaffa
;
Wan Zaidah Abdullah
- Publication Type:Case Reports
- Keywords:
anti-M, HDFN, Malay woman, recurrent pregnancy loss
- From:The Malaysian Journal of Pathology
2017;39(1):73-76
- CountryMalaysia
- Language:English
-
Abstract:
Haemolytic disease of the foetus and newborn (HDFN) is caused by maternal red blood cells (RBC)
alloimmunisation resulted from incompatibility of maternal and foetal RBCs. However, only a
few HDFN attributed to anti-M were reported, varying from asymptomatic to severe anaemia with
hydrops foetalis and even intrauterine death. A case of severe HDFN due to anti-M alloantibody
from an alloimmunized grandmultiparous Malay woman with recurrent pregnancy loss is reported
here. The newborn was delivered with severe and prolonged anaemia which required frequent RBC
transfusions, intensive phototherapy and intravenous immunoglobulin administration. Although
anti-M is rarely known to cause severe HDFN, a careful serological work-up and close assessment
of foetal well-being is important, similar to the management of RhD HDFN. Alloimmunisation with
anti-M type can lead to severe HDFN and even foetal loss.
- Full text:P020170515585381187497.pdf
