The Effect of Tamsulosin and Nifedipine on Expulsion of Ureteral Stones after Extracorporeal Shock Wave Lithotripsy.
10.4111/kju.2008.49.2.150
- Author:
Nak Young CHOI
1
;
Seung Hyun AHN
;
Jun Hyun HAN
;
In Ho JANG
Author Information
1. Department of Urology, KEPCO Medical Foundation Hanil General Hospital, Seoul, Korea. uroahn@dreamwiz.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Ureteral stones;
Extracorporeal shockwave lithotripsy;
Tamsulosin;
Nifedipine
- MeSH:
Benzilates;
Emergencies;
Humans;
Lithotripsy;
Nifedipine;
Nortropanes;
Shock;
Sulfonamides;
Ureter
- From:Korean Journal of Urology
2008;49(2):150-154
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We evaluated the effect of tamsulosin and nifedipine on expulsion of ureteral stones after extracorporeal shock wave lithotripsy(ESWL). MATERIALS AND METHODS: We evaluated 96 upper or lower ureteral stone patients. All patients received a single session of ESWL with a piezolith- 3000 and received twice-a-day oral treatment of 5mg trospium chloride. The patients were randomly divided into three groups. Group 1 received once a day oral therapy of 0.2mg tamsulosin. Group 2 received once a day oral therapy of 30mg nifedipine. Group 3 was used as the control group. All patients took oral medication for 2 weeks, and then we analyzed the stone expulsion rate, side effects, and mean numbers of emergency room(ER) visits for pain control. RESULTS: There were no differences in the 3 groups in stone size, location, age, and sex. The total stone expulsion rate was significantly higher in group 1(84.4%) compared with group 3(60.6%)(p=0.032). Patients with lower ureteral stones in group 1 showed a higher expulsion rate(94.1%) than those of group 3(66.7%)(p=0.042). There was no difference in stone expulsion rates between group 2(67.7%) and group 3(60.6%). CONCLUSIONS: These result suggest that adjunctive medical therapy with tamsulosin after an ESWL increased the stone expulsion rate of ureteral stones, especially lower ureteral stones.
