Infection associated haemophagocytic syndrome in severe dengue infection – a case series in a district hospital
- Author:
Jasmine Sze Yin Yew
;
Soon Liang Lee
;
Foong Kee Kan
- Publication Type:Case Reports
- Keywords:
Haemophagocytic syndrome;
Severe Dengue;
Hyperferritinemia;
HScore
- MeSH:
Severe Dengue
- From:
The Medical Journal of Malaysia
2017;72(1):62-64
- CountryMalaysia
- Language:English
-
Abstract:
Haemophagocytic lymphohistiocytosis (HLH) is a potentially
fatal disorder resulting from uncontrolled
hyperinflammatory response. There had been increase in
cases of one of the secondary form of HLH, i.e., infectionassociated
haemophagocytic syndrome (IAHS) in severe
dengue in recent years. However, the condition remains
under diagnosed due to lack of awareness compounded by
the lack of validated diagnostic criteria. Severe hepatitis
with prolonged cytopenias, severe hyperferritinemia,
hypofibrinogenemia and persistent fever were evident in all
four cases reported. All the subjects survived with
supportive care and adjuvant steroid therapy. Prospective
controlled studies are needed to develop diagnostic criteria
and management protocol for IAHS in severe dengue.
- Full text:P020170306395027263266.pdf
