Idiopathic thrombocytopenic purpura in childhood, Langerhans cell histiocytosis in adulthood: More than a chance association?
- Author:
Kuan Yueh Chien
;
Nurain Mohd Noor
- Publication Type:Case Reports
- Keywords:
Langerhans cell histiocytosis;
cranial diabetes insipidus;
idiopathic thrombocytopenic;
purpura;
hypothalamic-pituitary axis
- MeSH:
Histiocytosis, Langerhans-Cell
- From:
The Medical Journal of Malaysia
2017;72(1):50-52
- CountryMalaysia
- Language:English
-
Abstract:
Described herein, a case of Langerhans cell histiocytosis
(LCH) in an adult with Idiopathic Thrombocytopenic Purpura
(ITP) diagnosed at age ten. She presented with cranial
diabetes insipidus, later developed hypogonadotrophic
hypogonadism and multiple cervical lympadenopathy from
which histopathology of excisional biopsy confirmed LCH.
Magnetic resonance imaging showed thickened pituitary
stalk. Association of ITP and LCH is unknown but the
question of LCH presenting as isolated thrombocytopenia in
childhood only to be discovered in adulthood when there
was pituitary and bone involvement remains. It
reemphasizes the need for high index of suspicion and the
challenges in diagnosing LCH at the outset.
- Full text:P020170303582207268679.pdf
