A Multicenter Prospective Study of the Effect of Imipramine and Desmopressin on Arousability in Children with Nocturnal Enuresis.
10.4111/kju.2008.49.2.168
- Author:
Jun Mo KIM
1
;
Young Sig KIM
;
Mee Kyung NAMGOONG
;
Kwan Hyun PARK
;
Yong Hoon PARK
;
Sang Don LEE
;
Seung Joo LEE
;
Jae Yong CHUNG
Author Information
1. Department of Urology, College of Medicine, Soonchunhyang University, Bucheon, Korea. urojun@schbc.ac.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Nocturnal enuresis;
Arousal;
Imipramine;
Deamino arginine vasopressin
- MeSH:
Arousal;
Child;
Deamino Arginine Vasopressin;
Humans;
Imipramine;
Korea;
Nocturnal Enuresis;
Prospective Studies
- From:Korean Journal of Urology
2008;49(2):168-173
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We performed a multicenter, prospective study to evaluate the efficacy of imipramine and desmopressin to improve arousability and prevent nocturnal enuresis(NE). MATERIALS AND METHODS: The total of 48 children with NE were given questionnaires that included a scoring system for the assessing arousal from sleep. They were assigned into two groups: group 1(imipramine 25 mg, 3 girls and 16 boys, mean age 7.9 years), group 2(desmopressin 0.2 mg, 9 girls and 9 boys, mean age 7.5 years). The assessment of arousability was repeated 2 weeks and 4 weeks after medication. Eleven children were excluded because of incomplete data. RESULTS: Mean wetting events in group 1 decreased from 8.8 to 5.1 times(2 weeks) and 3.0 times(4 weeks)(p=0.009) versus 10.2 to 5.5 times(2 weeks) and 6.4 times(4 weeks)(p=0.007) for group 2. The mean threshold of arousability in group 1 was 4.9(baseline), 4.4(2 weeks), and 3.7(4 weeks), and, for group 2, 5.1(baseline), 4.8(2 weeks), and 4.8(4 weeks). The two groups were not different(p=0.14, p=0.73). CONCLUSIONS: Imipramine and desmopressin, which are commonly used in treating NE in Korea, influenced wetting events but not arousability.
