Treatment of Glucantime-resistant/tolerant cutaneous leishmaniasis with Lucilia sericata larvae and its larval secretions: The first study in the world
- Author:
Erdal Polat
- Publication Type:Journal Article
- From:Tropical Biomedicine
2016;33(4):668-674
- CountryMalaysia
- Language:English
-
Abstract:
Lucilia sericata larval secretions have bacteriostatic and bactericidal effects. We
investigated the effect of L. sericata larval secretions during passage from the third to the
second stage on Leishmania tropica under in vitro and in vivo conditions. The L. sericata
larvae and their secretions were also used in the treatment of cutaneous leishmaniasis
lesions. A total of 29 patients were included in this study. Seven patients were infected with
Glucantime-resistant Leishmania major. In 22 patients, there was no information about the
Glucantime resistance status and infection with L. tropica or L. major. All patients were
efficiently treated with L. sericata larvae and their secretions without leaving scar tissue.
Additionally, after 1-2 months of treatment, Leishmania spp. was not detected in the samples
using PCR.
- Full text:P020170123517568062466.pdf
