Acute promyelocytic leukaemia with a novel translocation t(16;17) (q12;p13): a case report
- Author:
Hilal Bhat, Sajad Geelani
;
Masrat Rashid
;
Tariq Bhat
;
Mudasir Qadr
;
Nusrat Bashir
;
Fahim Manzoor
;
Shuaeb Bhat
;
Fayaaz Rather
;
Javid Rasool
- Publication Type:Case Reports
- Keywords:
Novel translocation;
acute promyelocytic leukaemia;
fusion genes
- From:The Malaysian Journal of Pathology
2016;38(3):311-313
- CountryMalaysia
- Language:English
-
Abstract:
Acute promyelocytic leukaemia (APML) is characterised by the t(15;17)(q22;q21), that results in
the fusion of the promyelocytic leukaemia (PML) gene at 15q22 with the retinoic acid α-receptor
(RARA) gene at 17q21. The current case report describes a 13-year-old male with APML, who
was negative for PML/RARA fusion signal but reported to have an atypical translocation t(16;17).
To the best of our knowledge this is the first case report of APML responsive to ATRA with such
a translocation.
