MicroRNA expression in antiphospholipid syndrome: a systematic review and microRNA target genes analysis
- Author:
Suhiman Muhammad Shazwan
;
Mohamad Muhammad Aliff
;
Ahmad Asnawi Asral Wirda
;
Abdul Rahman Hayati
;
Masri Maizatul Azma
;
Abdul Rahim Nur Syahrina
;
Abdul Hamid Nazefah
;
Sathar Jameela
;
Mohd Manzor Nur Fariha
- Publication Type:Journal Article
- Keywords:
antiphospholipid syndrome;
antiphospholipid antibody;
autoimmune;
microRNA
- From:The Malaysian Journal of Pathology
2016;38(3):273-283
- CountryMalaysia
- Language:English
-
Abstract:
Antiphospholipid antibodies (aPL) are autoantibodies that attack phospholipid through anti-beta
2-glycoprotein 1. The actions of aPL are associated with events leading to thrombosis and morbidity
in pregnancy. Antiphospholipid syndrome (APS) is diagnosed when a patient is persistently positive
for aPL and also has recognised clinical manifestations such as recurrent pregnancy losses, arterial
or venous thrombosis and in a catastrophic case, can result in death. Unfortunately, the pathogenesis
of APS is still not well established. Recently, microRNA expressed in many types of diseased
tissues were claimed to be involved in the pathological progression of diseases and has become a
useful biomarker to indicate diseases, including APS. Objective: This systematic review aims to
search for research papers that are focussing on microRNA expression profiles in APS. Method:
Three search engines (Ebcohost, ProQuest and Ovid) were used to identify papers related to
expression of specific microRNA in antiphospholipid syndrome. Results and Discussion: A total of
357 papers were found and screened, out of which only one study fulfilled the requirement. In this
particular study blood samples from APS patients were tested. The microRNAs found to be related
to APS were miR-19b and miR-20a. No data was found on specific microRNA being expressed in
obstetric antiphospholipid syndrome. Analysis on the microRNA target genes revealed that most
genes targeted by miR-19b and miR-20a involve in TGF-Beta Signalling and VEGF, hypoxia and
angiogenesis pathways. Conclusion: In view of the limited data on the expressions of microRNA
in APS we recommend further research into this field. Characterization of microRNA profile in
blood as well as in placenta tissue of patients with APS could be useful in identifying microRNAs
involved in obstetric APS.
