Histopathological features of coeliac disease in a sample of Sudanese patients
- Author:
MA Noha Mokhtar
;
So Mekki
;
Hmy Mudawi
;
Sh Sulaiman
;
MA Tahir,MA Tigani, Ilham A Omer
;
Bm Yousif, Ishraga A Fragalla
;
Zulfa Mohammed
;
Mohamed Dafaalla
- Publication Type:Journal Article
- Keywords:
coeliac disease;
villous atrophy;
intraepithelial lymphocytosis;
Marsh grade;
Sudan
- From:The Malaysian Journal of Pathology
2016;38(3):267-272
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Coeliac disease can occur at any age but is more common in children. Its diagnosis
requires correlation between clinical presentations, serological results, endoscopic findings and
histopathological classification using the modified Marsh grading system. This study of coeliac
disease with biopsies received in the department of histopathology at Soba University Hospital,
and Fedail Hospital aimed to gain insight into the demographic profile, clinical presentations and
histopathological classification of patients with coeliac disease. Methods: This was a descriptive
study carried out at Soba University Hospital and Fedail Hospital during the period from January
2010-December 2013. Haematoxylin & Eosin and CD3-stained slides of small intestinal biopsies of
coeliac disease patients were reviewed for various histological features (1) intraepithelial lymphocytes
(IEL) count per 100 enterocytes, (2) crypt hyperplasia and (3) degree of villous atrophy. Based
on the histopathological findings, the cases were categorized according to the modified Marsh
classification. Demographic and clinical data were obtained from the patient request forms. The
data were analyzed using Statistical Package for Social Sciences Software (SPSS). Results: The
study included 60 patients. Their age ranged from 2 to 70 years with a mean of 19.5 years (±15.7
SD). The most common age group was below 10 years old (41.6%). Male and female are equally
affected. The most common clinical presentation was chronic diarrhoea (55.0%), followed by iron
deficiency anemia (41.7%). The degree of villous atrophy ranged from complete atrophy (45.0%),
marked atrophy (38.3%) to mild atrophy (16.6%). Marsh grade IIIC was the most common grade.
The younger age-groups had a higher prevalence of iron deficiency anaemia and higher Marsh grade.
