Diagnosing A Rare Case Of Desmoplastic Small Round Cell Tumour On Liver Biopsy
- Author:
Cheo Fan Foon
;
Leow Wei Qiang
- Publication Type:Case Reports
- Keywords:
Desmoplastic small round cell tumour;
liver biopsy;
EWSR1;
peritoneal tumour
- From:The Malaysian Journal of Pathology
2016;38(2):149-152
- CountryMalaysia
- Language:English
-
Abstract:
A 50-year-old male of Indian descent presented with jaundice and right hypochondrium pain.
Following a computed tomography (CT) scan of the abdomen, a segment 7 liver lesion was
visualized, accompanied by extensive peritoneal tumour deposits. An ultrasound guided liver biopsy
was performed and histology showed loose nests and sheets of tumour cells with a small blue round
cell morphology. The tumour cells showed patchy strong immunopositivity for cytokeratins (AE1/3,
CK7, CK19) and synaptophysin, while showing diffuse strong perinuclear positivity for desmin.
Interphase fluorescence in-situ hybridization (FISH) study using EWSR1 breakapart probe was
positive for EWSR1 gene rearrangement.
Desmoplastic small round cell tumour is a rare but aggressive intra-abdominal mesenchymal
tumour. While the primary sites of involvement are usually the peritoneum and omentum, visceral
involvement can occur. We wish to highlight the importance of considering this entity when
evaluating a liver biopsy especially in a less than classical clinical context.
- Full text:P020161005039672417846.pdf
