A Case of Pheochromocytoma with Ganglioneuronal Differentiation Producing Vasoactive Intestinal Peptide.
- Author:
Min Ah NA
1
;
Sang Soo KIM
;
Dong Uk KIM
;
Jae Hoon CHOI
;
Tae Kun LEE
;
Ok Nyu KONG
;
Jun Hyeop AN
;
Jee Yeon KIM
;
Han Dong SUNG
;
Chul Ho JOUNG
;
Seok Man SON
;
In Joo KIM
;
Yong Ki KIM
Author Information
1. Department of Internal Medicine, Pusan National University, Korea.
- Publication Type:Case Report
- Keywords:
Vasoactive intestinal peptide(VIP);
Pheochromocytoma
- MeSH:
Adenylyl Cyclases;
Blood Glucose;
Blood Pressure;
Diarrhea;
Electrolytes;
Female;
Humans;
Hypokalemia;
Middle Aged;
Neuroendocrine Tumors;
Neuropeptides;
Pheochromocytoma*;
Vasoactive Intestinal Peptide*;
Weight Loss
- From:Journal of Korean Society of Endocrinology
2003;18(2):227-231
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Vasoactive intestinal peptide(VIP) is a 28-amino acid peptide, which may cause secretory diarrhea by stimulating the production of adenylate cyclase. Neuroendocrine tumors, secreting vasoactive intestinal peptide (VIP), are almost always of a pancreatic in origin. However, a pheochromocytoma may produce several neuropeptides, containing VIP, as they are considered to be neuroendocrine tumors. A 57-year-old woman, who presented with chronic watery diarrhea, hypokalemia, weight loss and a left adrenal mass, is described. Histologically, the tumor was diagnosed as a pheoch-romocytoma, with ganglioneuronal differentiation, and was histochemically confirmed to produce a vasoactive intestinal polypeptide. A left adrenal VIP-producing pheochromocytoma was successfully resected. After surgery, her diarrhea subsided and the electrolytes, affected neuroendocrine hormone levels, blood pressure and blood sugar level were normalized.
