Community-acquired bacteremia in Paediatrics:Epidemiology, aetiology and patterns of antimicrobial resistance in a tertiary care centre, Malaysia
- Author:
Nor Azizah Abu
;
Fadzilah Mohd Nor
;
Mariam Mohamad
;
Anis Siham Zainal Abidin
;
Ariza Adnan
;
Noor Shafina Mohd Nor
;
A Anita Kaur
- Publication Type:Journal Article
- Keywords:
Community acquired bacteraemia;
antimicrobial/antibiotic resistance;
children
- MeSH:
Anti-Infective Agents;
Bacteremia
- From:
The Medical Journal of Malaysia
2016;71(3):117-121
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: bacteremia continues to be one of the major
causes of morbidity and mortality despite the existence of
numerous antimicrobial agents. this study aimed to provide
a Malaysian perspective on paediatric community-acquired
bacteraemia based on the documentation of epidemiology
and antimicrobial profile of the isolated pathogens.
Method: A retrospective study was conducted by analysing
clinical details, blood cultures and antimicrobial
susceptibility testing results in children between the ages of
0 to 13 years old, who were admitted to selayang Hospital
over an 11-year period from 2001 until 2011. there were 222
bacteraemia cases and the median age was 11.7 months.
the highest number (39%) of bacteraemia cases occurred
between ages one month to one year. the three most
commonly isolated aetiological agents were
Staphylococcus aureus (17.1%), nontyphoidal Salmonella
(16.2%), and Streptococcus pneumoniae (12.6%). Almost 8%
of the Staphylococcus aureus isolates were methicillin
resistant, while nontyphoidal Salmonella (Nts) isolates
demonstrated 18.4%, 10.5% and 2.6% resistance towards
ampicillin, trimethoprim-sulfamethoxazole and ciprofloxacin
respectively. All Nts isolates were sensitive to ceftriaxone.
Streptococcus pneumoniae isolates showed 17.9%
resistance to penicillin. skin and soft tissue infections as
well as lower respiratory tract infections (63.2%) were the
main foci of infections in Staphylococcus aureus
bacteraemia. Acute gastroenteritis (80.0%) and pneumonia
(60.8%) were the main presentations of Nts and
Streptococcus pneumoniae bacteraemia respectively.
Overall mortality rate was 8.1%.
Conclusion: Knowledge on the local epidemiology and
antibiotic resistance pattern serves as a significant platform
in improving the empiric antibiotic therapy for patients with
community acquired bacteraemia.
- Full text:P020160808603244513113.pdf
