Phyllodes tumours of the breast: retrospective analysis of a University Hospital’s experience
- Author:
Toh YF
;
Cheah PL
;
Looi LM
;
Teoh KH
;
Tan PH
- Publication Type:Journal Article
- Keywords:
phyllodes tumour;
breast;
Malaysian
- From:The Malaysian Journal of Pathology
2016;38(1):19-24
- CountryMalaysia
- Language:English
-
Abstract:
Taking cognizance of the purported variation of phyllodes tumours in Asians compared with Western
populations, this study looked at phyllodes tumours of the breast diagnosed at the Department of
Pathology, University of Malaya Medical Centre over an 8-year period with regards to patient
profiles, tumour parameters, treatment offered and outcome. Sixty-four new cases of phyllodes
tumour were diagnosed during the period, however only 30 (21 benign, 4 borderline and 5 malignant)
finally qualified for entry into the study. These were followed-up for 4-102 months (average = 41.7
months). Thirteen cases (8 benign, 3 borderline, 2 malignant) were Chinese, 9 (all benign) Malay,
7 (4 benign, 1 borderline, 2 malignant) Indian and 1 (malignant) Indonesian. Prevalence of benign
versus combined borderline and malignant phyllodes showed a marginally significant difference
(p=0.049) between the Malays and Chinese. Patients’ ages ranged from 21-70 years with a mean of
44.9 years with no significant difference in age between benign, borderline or malignant phyllodes
tumours. Except for benign phyllodes tumours (mean size = 5.8 cm) being significantly smaller
at presentation compared with borderline (mean size = 12.5 cm) and malignant (mean size = 15.8
cm) (p<0.05) tumours, history of previous pregnancy, breast feeding, hormonal contraception and
tumour laterality did not differ between the three categories. Family history of breast cancer was
noted in 2 cases of benign phyllodes. Local excision was performed in 17 benign, 2 borderline and
3 malignant tumours and mastectomy in 4 benign, 2 borderline and 2 malignant tumours. Surgical
clearance was not properly recorded in 10 benign phyllodes tumours. Six benign and all 4 borderline
and 5 malignant tumours had clearances of <10 mm. Two benign tumours recurred locally at 15
and 49 months after local excision, however information regarding surgical clearance was not
available in both cases. One patient with a malignant tumour developed a radiologically-diagnosed
lung nodule 26 months after mastectomy, was given a course of radiotherapy and remained well
8-months following identification of the lung nodule.
- Full text:P020160531441591938738.pdf
