Malignant Transformation Of Breast Ductal Adenoma: A Diagnostic Pitfall
- Author:
Hiroko Hayashi
;
Hiroshi Ohtani
- Publication Type:Journal Article
- Keywords:
ductal adenoma;
adenomyoepithelioma;
papilloma;
epithelial–myoepithelial carcinoma;
breast tumour
- From:The Malaysian Journal of Pathology
2015;37(3):281-285
- CountryMalaysia
- Language:English
-
Abstract:
We present what is believed to be the first report of heterogeneous carcinoma arising from breast ductal
adenoma. A 57-year-old woman presented with a nodule in her right breast. Histological examination
of a vacuum-assisted biopsy specimen revealed epithelial tubular proliferation and papillary apocrine
epithelium. The myoepithelial cells lining the tubules were confirmed by immunohistochemistry.
The nodule had increased in size 18 months later and tumorectomy was performed. The surgical
specimen revealed proliferating apocrine epithelium with sheet-like and cribriform architecture
within a mammary duct. Some myoepithelial cells showed irregular proliferation around the tubular
epithelium. All three components, including apocrine, myoepithelial and glandular cells, showed
prominent nuclear atypia and significant mitotic activity. The patient was diagnosed with malignant
transformation of ductal adenoma. The malignant potential of ductal adenoma has not previously
been discussed, but this heterogeneous carcinoma could represent a serious pitfall in the diagnosis
of ductal adenomas.
- Full text:P020160315423443161561.pdf
