Minichromosome Maintenance-2 (MCM2) Expression Differentiates Oral Squamous Cell Carcinoma From Pre-Cancerous Lesions
- Author:
Seyed Mohammad Razavi
;
Maryam Jafari
- Publication Type:Journal Article
- Keywords:
dysplasia;
hyperkeratosis;
squamous cell carcinoma;
minichromosome maintenance
- From:The Malaysian Journal of Pathology
2015;37(3):253-258
- CountryMalaysia
- Language:English
-
Abstract:
Background: Proteins necessary for DNA replication and normal regulation for the cell cycle include
minichromosome maintenance-2 (Mcm-2). Overexpression of this protein in several premalignant
and malignant lesions has been observed. In this study, the diagnostic value of Mcm-2 expression in
distinguishing histologically-proven normal oral mucosa (NOM), oral benign keratosis (OBK), oral
epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC) was investigated. Materials
and Methods: In this descriptive analytical study, 73 archived specimens of oral tissues, including
20 OBK, 20 OED, 20 OSCC, and 13 NOM cases were selected. The means of labeling indices (LIs)
of Mcm-2 expression by immunohistochemistry in each category of lesions were calculated. The
data was analyzed by one–way ANOVA, discriminant analysis, and Fisher’s exact tests. Results:
The means of labeling indices (LIs) of Mcm-2 expression show statistically significant difference
between the four studied groups (P<0.001). Mcm-2 had overexpression and higher positivity in
OSCCs. A cut-off point of 67% was determined in order to distinguish OSCC from precancerous
lesions. Conclusion: The findings indicated that Mcm-2 could be a useful marker for early detection
of oral SCC and dysplasia. Also, due to the overexpression of this marker in OSCC, there exists the
possibility of application of Mcm-2 for molecular target therapy in these patients.
- Full text:P020160315417147693097.pdf
