Serum Fasting Lipid Profile In Children And Adolescents With -Thalassaemia Major In Southern Pakistan
- Author:
Sana Ashar
;
Sadia Sultan
;
Syed Mohammed Irfan
- Publication Type:Journal Article
- Keywords:
β-thalassaemia major;
triglyceride;
HDL-cholesterol;
LDL-cholesterol
- From:The Malaysian Journal of Pathology
2015;37(3):233-238
- CountryMalaysia
- Language:English
-
Abstract:
Objective: Serum fasting lipid profile has been studied in various clinical spectrum of Beta (β)-
thalassaemia syndrome. Premature cardiac impairment in thalassaemia major appears primarily due
to iron accumulation and oxidative injury; however it might be a sequel of abnormal lipoprotein
concentrations. The rational of this study is to analyse the serum fasting lipid profile in cardiovascular
disease free β-thalassaemia major (β-TM) patients. Relationships with age, gender, haematological
parameters, liver enzymes and serum ferritin were observed. Method: Fasting serum lipid levels,
liver function test (LFT), complete blood count (CBC) and serum ferritin were measured in 36
patients with homozygous β-TM from March 2012 to March 2014. Patients were stratified into
two groups, age ≤15 and >15 years, to determine the possible lipid profile distinction in relation
to age. Results: 17 were males and 19 were females, with median age of 12.0 years. The mean
total cholesterol (TC) and triglyceride (TG) were 5.01±1.32 and 8.36±5.28 mmol/L respectively.
High TG was detected in 36.1%, while high density lipoprotein cholesterol (HDL) and low density
lipoprotein cholesterol (LDL) were markedly low, 0.98±0.51 and 2.35±1.22 mmol/L respectively.
No statistically significant difference was noted between the two age groups. The median TC to HDL
ratio (TC:HDL) was elevated, 5.7 (4.0). We established significant correlation of total bilirubin with
TC (r=-0.4), HDL(r=-0.5) and LDL (r=-0.4) (P<0.05). Conclusion: Dyslipidaemia in β-TM patients
is irrespective of age and gender including low HDL and high TC:HDL, whilst high TC:HDL may
contribute as a significant risk marker for future cardiac events in these patients.
- Full text:P020160315413693322304.pdf
