Causes of mortality in patients with psoriasis in Malaysia –Evidence from the Malaysian Psoriasis Registry
- Author:
Zhenli Kwan
;
Chin Aun Yeoh
;
Azura Mohd Affandi
;
Fatimah Afifah Alias
;
Muneer Hamid
;
Nurakmal Baharum
;
Adrian Sze Wai Yong
;
Roshidah Baba
- Publication Type:Journal Article
- Keywords:
Psoriasis;
epidemiology;
mortality
- MeSH:
Psoriasis
- From:
The Medical Journal of Malaysia
2015;70(5):273-277
- CountryMalaysia
- Language:English
-
Abstract:
Background: Patients with severe psoriasis, namely those
requiring phototherapy or systemic treatment, have an
increased risk of death. The aim of this study was to
determine the prevalence, aetiology and risk factors for
mortality among adult patients aged 18 years and above with
psoriasis in Malaysia.
Methods: This was a retrospective study involving adult
patients notified by dermatologists to the Malaysian
Psoriasis Registry between July 2007 and December 2013.
Data were cross-checked against the National Death
Registry. Patients certified dead were identified and the
cause of death was analysed. Multivariate analysis using
multiple logistic regression were conducted on potential
factors associated with higher risk of mortality.
Results: A total of 419 deaths were identified among the
9775 patients notified. There were four significant risk
factors for higher mortality: age>40 years (age 41-60 years
old, Odds Ratio (OR) 2.70, 95%CI 1.75, 4.18; age>60 years
OR 7.46, 95%CI 4.62, 12.02), male gender (OR 1.72, 95%CI
1.33,2.22), severe psoriasis with body surface area (BSA)
>10% (OR 1.52, 95%CI 1.19, 1.96) and presence of at least
one cardiovascular co-morbidity (OR 1.67, 95% CI 1.30,
2.14). Among the 301 patients with verifiable causes of
death, the leading causes were infection (33.9%),
cardiovascular disease (33.6%) and malignancy (15.9%).
Conclusion: Infection was the leading cause of death among
psoriasis patients in Malaysia. Although cardiovascular
diseases are well-known to cause significant morbidity and
mortality among psoriasis patients, the role of infections
and malignancy should not be overlooked.
- Full text:P020151109526663810023.pdf
