HLA DR/DQ type in a Malay population in Kelantan, Malaysia
- Author:
Azira Nms
;
Zeehaida M
;
Nurul Khaiza Yahya
- Publication Type:Journal Article
- Keywords:
HLA DR/DQ typing;
Malay;
Malaysian
- From:The Malaysian Journal of Pathology
2013;35(1):65-69
- CountryMalaysia
- Language:English
-
Abstract:
The human leucocyte antigen (HLA) has been documented to be involved in various disease
susceptibilities or in resistance against certain diseases. An important element in susceptibility and
resistance to disease is ethnic genetic constitution. Cognizant of this, the present study aimed at
studying the prevalence of particular HLA class II in a normal healthy Malay population which
may serve as a guide for further genetic and immunological studies related to the Malay Malaysian
population. The study involved 40 normal healthy Malay persons in Kelantan. HLA typing was
conducted on venous blood samples through a polymerase chain reaction-sequence specifi c primer
method (low resolution Olerup SSP® HLA Typing Kits). The study found HLA DR12 and HLA
DQ8 to be the most frequent HLA class II type. HLA DQ5 was signifi cantly associated with female
subjects.
- Full text:P020150925360425138668.pdf
