Pattern of hMLH1, hMSH2 and hMSH6 expression and clinical characteristics in a sample of Malaysian colorectal carcinoma cases
- Author:
Joon-Joon Khoo
;
Andrew Gunn
;
Suat-Cheng Peh
- Publication Type:Journal Article
- Keywords:
mismatch repair defect;
colorectal carcinoma;
immunohistochemical stain
- From:The Malaysian Journal of Pathology
2013;35(1):45-57
- CountryMalaysia
- Language:English
-
Abstract:
Malignant transformation from normal colonic mucosa to carcinomas may be accelerated by
genetic loss or inactivation of genes of the DNA mismatch repair system. The aim of the study
was to determine the local incidence and pattern of immunohistochemical expression of mismatch
repair proteins namely: hMLH1, hMSH2 and hMSH6 in a series of colorectal carcinomas (CRCs)
and correlate this to their clinical and pathological features. Forty-three out of 298 cases of CRCs
(14.4%) showed abnormal staining pattern for mismatch repair proteins with a majority (65.1%)
showing single hMLH1 loss. Tumours with mismatch repair defect (MMR-d) were frequently found
at the right side of colon (p<0.001), poorly differentiated carcinomas (p<0.001), produced more
mucin (p=0.007), exophytic growth (p=0.007) and were bigger (p=0.002) than tumours with no
mismatch repair defect. Immunohistochemical stains for mismatch repair proteins could be done in
local laboratories on these selected cases before referring for the expensive molecular test.
- Full text:P020150925345195917915.pdf
