SNP array technology: an array of hope in breast cancer research
- Author:
Ching Ching Ho
;
Kein-Seong Mun
;
Rakesh Naidu
- Publication Type:Review
- Keywords:
breast carcinoma;
microarray;
single-nucleotide-polymorphism;
comparative genomic hybridization;
loss of heterozygosity
- From:The Malaysian Journal of Pathology
2013;35(1):33-43
- CountryMalaysia
- Language:English
-
Abstract:
Breast cancer is the most common malignancy in women worldwide. The incidence of breast
cancer in Malaysia is lower compared to international statistics, with peak occurrence in the age
group between 50 to 59 years of age and mortality rates of 18.6%. Despite current diagnostic and
prognostic methods, the outcome for individual subjects remain poor. This is in part due to breast
cancers’ wide genetic heterogeneity. Various platforms for genetics studies are now employed
to determine the identity of these genetic abnormalities, including microarray methods like highdensity
single-nucleotide-polymorphism (SNP) oligonucleotide arrays which combine the power of
chromosomal comparative genomic hybridization (cCGH) and loss of heterozygosity (LOH) in the
offering of higher-resolution mappings. These platforms and their applications in highlighting the
genomic alteration frameworks manifested in breast carcinoma will be discussed.
- Full text:P020150925340028108962.pdf
