Obesity-related complications: few biochemical phenomena with reference to tumorigenesis
- Author:
Kirolos Iskander
;
Reza Farhour
;
Monica Ficek
;
Amitabha Ray
- Publication Type:Review
- Keywords:
Obesity;
cancer;
insulin resistance;
cholesterol;
oestrogen;
adipokines;
clinical biochemistry
- From:The Malaysian Journal of Pathology
2013;35(1):1-15
- CountryMalaysia
- Language:English
-
Abstract:
Overweight or obesity is currently a common health problem in westernized societies globally.
Obesity is linked with a sizeable number of disease aetiologies, notably type-2 diabetes, cardiovascular
disorders and certain cancers, perhaps through some common mechanisms that favor persistent
low-grade infl ammation. Both epidemiological and laboratory studies have demonstrated that the
pathogenesis of certain cancers and the related prognosis are infl uenced by obesity. Clinically, a
complex situation is present in obesity, which usually shows higher blood levels of various biomolecules,
e.g., lipids like triglycerides, hormones like insulin, and fat cell-secreted adipokines
like leptin. On the contrary, obesity is associated with lower concentrations of substances like sex
hormone-binding globulin and adiponectin. Many of these biochemical compounds are used routinely
for clinical diagnosis and assessment during the follow-up period. Nonetheless, approximately
one-fi fth of the total cancer burden is associated with obesity. Excess adipose tissue and different
hormonal substances possibly play a signifi cant role in this complex obesity-related carcinogenesis.
A precise understanding of the pertinent pathological processes is defi nitely useful in early diagnosis,
clinical management, and designing of novel pharmaceutical agents.
- Full text:P020150925334447792171.pdf
