Sinonasal haemangiopericytoma: histomorphology and differential diagnoses
- Author:
Wei Qiang Leow
;
Ivy SNG
- Publication Type:Case Reports
- Keywords:
nasal tumour;
haemangiopericytoma;
CD99;
CD34
- From:The Malaysian Journal of Pathology
2015;37(1):53-56
- CountryMalaysia
- Language:English
-
Abstract:
A 39-year-old female presented with a fleshy nasal polyp occluding the left nasal cavity, associated
with haemopurulent discharge. Computed Tomography (CT) and Magnetic Resonance Imaging
(MRI) scans of the paranasal cavities revealed a large polypoid tumour arising from the left
middle turbinate and obstructing the left maxillary sinus ostium. However, no bony or intracranial
involvement was identified. A biopsy revealed a tumour with small blue round cell morphology.
The tumour cells showed diffuse strong membranous CD99 positivity and patchy CD34 positivity.
Ancillary cytogenetic tests for the EWSR1 and SS18/SYT gene translocations were negative. In
view of the non-invasive nature of the tumour and the low cell proliferative index (Ki-67) of 5%,
a medial maxillectomy resection was performed. The resection revealed additional areas with
spindle-cell morphology and focal haemangiopericytic vasculature. The tumour continued to show
immunoreactivity to CD99 and CD34, as well as Smooth Muscle Actin (SMA) and Muscle Specific
Actin (MSA). The overall findings are in keeping with a sinonasal haemangiopericytoma. With clear
surgical resection margins, the patient is on routine follow-up and is currently disease-free.
- Full text:P020150915427596023364.pdf
