Bacterial pathogens and antibiotic resistance patterns in children with urinary tract infection in a Malaysian tertiary hospital
- Author:
Noor Shafina Mohd Nor
;
Nor Azizah Abu
;
Mohammad Abdur Rashid
;
Faisal Mohd Fadzli
;
Mohamad Ikhsan Selamat
;
Hafizah Zainuddin
;
Anis Siham Zainal Abidin
;
Wan Jazilah Wan Ismail
;
Raja Khuzaiah Raja Abdul Razak
- Publication Type:Journal Article
- Keywords:
Urinary tract infection;
antibiotic/antimicrobial
- MeSH:
Urinary Tract Infections
- From:
The Medical Journal of Malaysia
2015;70(3):153-157
- CountryMalaysia
- Language:English
-
Abstract:
SUMMARY
Introduction: Urinary tract infection (UTI) is a common
bacterial infection affecting children and therefore, prompt
recognition and accurate antimicrobial management are
vital to prevent kidney damage. This study aims to
determine the bacterial pathogens and their patterns of
antimicrobial resistance in children presenting with UTI.
Methods: A retrospective study of 721 cases, involving
children between the ages of 1-day old to 13 years old with
culture-proven UTI in Selayang Hospital, Malaysia between
January 2007 and December 2011. The bacterial pathogens
and antibiotic resistance patterns in the total population,
prophylaxis and no prophylaxis groups were studied.
Results: The 3 most common organisms isolated in the total
population were E.Coli (41.6%), Klebsiella spp. (21.2%) and
Enterococcus spp. (11.0%). With regards to the antibiotic
resistance, E.Coli resistance rates to ampicillin, cefuroxime
and gentamicin were 67.7%, 15.3% and 7.3% respectively.
Ampicillin-resistance was also highest in Klebsiella spp.
(84.3%), Enterococcus spp. (15.5%) and Proteus spp.
(55.5%).
Conclusion: E.coli remains to be the leading bacterial
pathogen causing UTI in children, with ampicillin-resistance
occurring in more than half of these cases. Therefore,
accurate choice of antibiotics is important to ensure optimal
outcome. In our study, cefuroxime and gentamicin have
lower antibiotic resistance rates and can be used in the
treatment of UTI in children.
- Full text:P020150904393060593238.pdf
