A Review of Colorectal Cancer Research in Malaysia
- Author:
Lim Kean Ghee
- Publication Type:Review
- Keywords:
Colorectal cancer;
Malaysia;
Review;
genetics;
screening;
diagnosis;
staging;
treatment;
outcome
- From:
The Medical Journal of Malaysia
2014;69(Supplement A):23-32
- CountryMalaysia
- Language:English
-
Abstract:
105 articles related to colorectal cancer(CRC) were found in a
search through a database dedicated to indexing all original
data relevant to medicine published in Malaysia between the
years 2000-2013. 56 articles were selected and reviewed on
the basis of clinical relevance and future research
implications. Research into the genetic basis for colorectal
cancer included studies in germline mutations of known
syndromes as well as polymorphisms that conferred
individuals a higher odds ratio for developing CRC. Several
studies also documented the variety of somatic mutations
seen in cases of sporadic CRC in Malaysia. Studies into the
knowledge and attitudes of Malaysians regarding CRC
revealed poor appreciation of the common symptoms, risk
factors and available measures for its early detection. This
may explain the observed facts that more Malaysians present
with late stage CRC than seen in developed countries. The
small amount of data recorded concerning the outcome of
treatment also suggests overall survival of Malaysian CRC
patients for comparable stage of CRC is lower than achieved
in developed countries.
KEY WORDS: Colorectal cancer; Malaysia; Review; genetics;
screening; diagnosis; staging; treatment; outcome
- Full text:P020150729527106311236.pdf
