Insufficiency Fractures Related to Low-Dose Adefovir Dipivoxil Treatment for Chronic Hepatitis B
- Author:
Feng Poh
;
Benjamin Wei Heng Sing
;
P. Chandra Mohan
- Publication Type:Journal Article
- Keywords:
Insufficiency fracture;
stress fracture;
femoral fracture;
osteomalacia;
Adefovir
- MeSH:
Osteomalacia
- From:
The Medical Journal of Malaysia
2015;70(1):38-41
- CountryMalaysia
- Language:English
-
Abstract:
We present a case of a 53-year-old woman who developed
multifocal insufficiency fractures associated with adefovir
dipivoxil (ADV) induced osteomalacia, including recurring
metatarsal insufficiency fractures and a subtrochanteric
femoral insufficiency fracture requiring surgical fixation.
She had received low-dose ADV treatment for 59 months for
chronic hepatitis B viral infection at the time of presentation
with subtrochanteric fracture. Imaging evidence of
multifocal insufficiency fractures and metabolic disease on
background of hypophosphatemia is attributed to
hypophosphatemic osteomalacia from adefovir-induced
renal proximal tubular dysfunction. Radiologists and
clinicians should be aware of the possibility of insufficiency
fractures in patients receiving ADV therapy to avoid delayed
diagnosis and progression of high-risk proximal femoral
fractures.
- Full text:P020150724518311471679.pdf
