Immunochemical Faecal Occult Blood Test for Colorectal Cancer Screening: A Systematic Review
- Author:
Syful Azlie Md Fuzi
;
Muhammad Radzi Abu Hassan
;
Junainah Sabirin
;
Rugayah Bakri
- Publication Type:Journal Article
- Keywords:
Systematic review;
IFOBT;
colorectal cancer screening
- MeSH:
Colorectal Neoplasms
- From:
The Medical Journal of Malaysia
2015;70(1):1-30
- CountryMalaysia
- Language:English
-
Abstract:
A systematic review on the effectiveness and costeffectiveness
of Immunochemical faecal occult IFOBT for
CRC screening was carried out. A total of 450 relevant titles
were identified, 41 abstracts were screened and 18 articles
were included in the results. There was fair level of
retrievable evidence to suggest that the sensitivity and
specificity of IFOBT varies with the cut-off point of
haemoglobin, whereas the diagnostic accuracy performance
was influenced by high temperature and haemoglobin
stability. A screening programme using IFOBT can be
effective for prevention of advanced CRC and reduced
mortality. There was also evidence to suggest that IFOBT is
cost-effective in comparison with no screening, whereby a
two-day faecal collection method was found to be costeffective
as a means of screening for CRC. Based on the
review, quantitative IFOBT method can be used in Malaysia
as a screening test for CRC. The use of fully automated
IFOBT assay would be highly desirable.
- Full text:P020150724516686314596.pdf
