Urinary type IV collagen levels in diabetes mellitus
- Author:
Pavai Sthaneshwar
;
Siew-Pheng Chan
- Publication Type:Journal Article
- Keywords:
Type IV collagen, type 2 diabetes mellitus, urine microalbumin
- From:The Malaysian Journal of Pathology
2010;32(1):43-47
- CountryMalaysia
- Language:English
-
Abstract:
Type IV collagen is the principal component of glomerular basement membrane and messangial
matrix. Studies have shown increased levels of urinary type IV collagen (uIV) in diabetic patients
compared to healthy controls. The concentration of uIV increases gradually as diabetic nephropathy
progresses. Aim and method: This study was carried out to determine whether urinary type IV collagen
(uIV) can serve as an indicator of diabetic nephropathy. Using a sandwich enzyme immunoassay
technique, uIV excretion was determined in 30 type 2 diabetic patients with normoalbuminuria and
20 patients with microalbuminuria. Results: uIV excretion was signifi cantly increased in type 2
diabetics, in both normoalbuminuric and microalbuminuric patients, compared with healthy controls.
The increase in urinary type IV collagen was well correlated with the amount of urinary albumin
but not with HbA1C. Conclusion: Our fi ndings that uIV is higher in those with microalbuminuria
and correlates with albuminuria, support uIV as an indicator of diabetic nephropathy. Whether the
increased uIV excretion would predict the impending renal failure needs further confi rmation.
- Full text:W020151209334678443529.pdf
