Pregnancy Outcomes Compared in Women with Mechanical Heart Valve Replacements Anticoagulated with Warfarin and Enoxaparin in Pregnancy
- Author:
Vijayan Valayatham
;
Rachel Thundyil
- Publication Type:Journal Article
- Keywords:
Mechanical Heart Valve, Pregnancy, Heparin, Low Molecular Weight Heparin, Warfarin
- From:
The Medical Journal of Malaysia
2012;67(6):591-594
- CountryMalaysia
- Language:English
-
Abstract:
The anticoagulation of choice for mechanical heart valves is the oral anticoagulant warfarin. Warfarin is associated with increased risk of miscarriage, intrauterine fetal deaths and warfarin embryopathy. This longitudical cross-over study of 5 women observed all 5 having livebirths of healthy infants after heparin-managed pregnancies. Their earlier 8 pregnancies had all resulted in perinatal losses or miscarriages when on regimes based on warfarin.
