Effectiveness of Antihypertensive Drugs in Hypertensive Patients With End Stage Renal Failure
- Author:
Endang Kumolosasi
;
Wen Bin Ng
;
Siti Azdiah Abdul Aziz
- Publication Type:Journal Article
- Keywords:
Antihypertensive drugs;
efficacy;
end stage renal failure;
hypertension;
combination therapy
- From:
The Medical Journal of Malaysia
2012;67(4):379-385
- CountryMalaysia
- Language:English
-
Abstract:
Hypertension has been identified as one of the causes for
end stage renal failure (ESRF) and is likely to worsen kidney function. This retrospective study was carried out at a tertiary hospital in Malaysia with the objective of
determining the effectiveness of combination
antihypertensive drugs in hypertensive patients with ESRF
admitted between 2006 and 2008. Patients with incomplete
data and who were on monotherapy were excluded from this
study. Although six different combinations gave significant
reductions in systolic blood pressure (SBP) (13.38 ± 9.11
mmHg, p<0.05) and diastolic blood pressure (DBP) (6.03 ±
11.39 mmHg, p<0.05), 69.16% patients did not achieve target
blood pressure (BP) (≤ 130/80 mmHg). Combination of beta
blocker (BB) with calcium channel blocker (CCB) was the
most commonly used. The CCB-diuretic regimen achieved
highest percentage of BP control compared to others (40%).
Comparison of blood pressure reduction between different
combinations of antihypertensive drugs were not significant
(p>0.05) except for CCB-diuretics and BB-CCB-alpha
blocker. The findings suggested better BP control with CCB-diuretic relative to other combinations used.
