Does Oral Lansoprazole Really Reduce Gastric Acidity in VLBW Premature Neonates?
- Author:
Tham Sock Ying
;
Rogers Ian M
;
Samuel KF
;
Singh A
;
Ong King Kok
- Publication Type:Journal Article
- Keywords:
Preterm neonate/VLBW/ acid gastro esophageal reflux/proton pump inhibitor/omeprazole/ neonatal hyperacidity/neonatal hypergastrinaemia
- From:
The Medical Journal of Malaysia
2012;67(3):284-288
- CountryMalaysia
- Language:English
-
Abstract:
Premature neonates of very low birth weight (VLBW) whose
treatment required the use of naso-gastric tube feeding were investigated. 10 infants suspected of having GERD (gastroesophageal reflux) received oral lansoprazole therapy by tube administration. 9 other infants formed a control group.
In the treated group a fasting pH was determined before
treatment and again after 7 days treatment. The control
group was similarly assessed at an interval of 7 days. Despite acid reduction, the post-treatment pH mean of 1.31 would continue to pose a threat to the esophageal mucosa. The physiology of neonatal acid secretion is discussed to explain these findings.
