The Presence of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus (heteroVISA) in a Major MalaysianHospital
- Author:
Norazah Ahmad
;
Law Ngiik Ling
;
Mohamed Kamel Abd Ghani
;
Salbiah Nawi
- Publication Type:Journal Article
- Keywords:
MRSA, HeteroVISA, Etest GRD, population analysis, pulsed-field gel electrophoresis
- From:
The Medical Journal of Malaysia
2012;67(3):269-273
- CountryMalaysia
- Language:English
-
Abstract:
This study was conducted to detect the presence of
heterogenous vancomycin-intermediate Staphylococcus
aureus (heteroVISA) among MRSA isolates in a major
hospital. Forty-three MRSA isolates with vancomycin MIC 2
μg/ml collected in 2009 was screened for heteroVISA using
Etest Glycopeptide Resistance Detection (GRD) and
confirmed by population analysis profile-area under curve
method. The genetic relatedness of heteroVISA strains with
other MRSA was examined by pulsed-field gel
electrophoresis (PFGE) method. Two isolates were shown to
be heteroVISA and derived from the same clone. This showed
that heteroVISA strains were already present among our
local strains since 2009 and were genetically related to other susceptible strains.
