Real space flight travel is associated with ultrastructural changes, cytoskeletal disruption and premature senescence of HUVEC
- Author:
MY Kapitonova
;
S Muid
;
GRA Froemming
;
WNW Yusoff
;
S Othman
;
AM Ali
;
HM Nawawi
- Publication Type:Journal Article
- Keywords:
endothelium, microgravity, cell growth, cytoskeleton, senescence
- From:The Malaysian Journal of Pathology
2012;34(2):103-113
- CountryMalaysia
- Language:English
-
Abstract:
Microgravity, hypergravity, vibration, ionizing radiation and temperature fluctuations are major factors
of outer space flight affecting human organs and tissues. There are several reports on the effect
of space flight on different human cell types of mesenchymal origin while information regarding
changes to vascular endothelial cells is scarce.
Ultrastructural and cytophysiological features of macrovascular endothelial cells in outer space
flight and their persistence during subsequent culturing were demonstrated in the present investigation.
At the end of the space flight, endothelial cells displayed profound changes indicating cytoskeletal
lesions and increased cell membrane permeability. Readapted cells of subsequent passages
exhibited persisting cytoskeletal changes, decreased metabolism and cell growth indicating cellular
senescence.
- Full text:W020151218565957007451.pdf
