Leukaemic stem cells: Drug resistance, metastasis and therapeutic implications
- Author:
Rebecca SY Wong
;
Soon-Keng Cheong
- Publication Type:Review
- Keywords:
Leukaemic stem cells, drug resistance, metastasis, therapeutic targets
- From:The Malaysian Journal of Pathology
2012;34(2):77-88
- CountryMalaysia
- Language:English
-
Abstract:
Although there have been many new developments in the treatment of leukaemia with the use
of new anti-leukaemic agents and stem cell transplantation, drug resistance and treatment failure
remain a great challenge for the attending physician. Several studies have suggested that leukaemic
stem cells (LSCs) play a pivotal role in chemoresistance and metastasis and the mechanisms by
which these cells do so have also been elucidated. There is increasing evidence to show that there
exists a large pool of therapeutic targets in LSCs and that the eradication of these cells is feasible
with some promising results. This article gives an overview of different types of cancer stem cells
(CSCs) derived from various types of leukaemia, the mechanisms by which LSCs contribute to drug
resistance and metastasis and some recent advances in targeted therapy against LSCs.
- Full text:W020151218436737637563.pdf
