Serum total protein, albumin and advanced oxidation protein products (AOPP) - implications in oral squamous cell carcinoma
- Author:
Abhishek Singh Nayyar
;
Mubeen Khan
;
Vijayalakshmi KR
;
Suman B
;
Gayitri HC
;
Anitha M
- Publication Type:Journal Article
- Keywords:
Oral squamous cell carcinoma, reactive oxygen species, transformation, pre-cancerous, serum albumin.
- From:The Malaysian Journal of Pathology
2012;34(1):47-52
- CountryMalaysia
- Language:English
-
Abstract:
Background: The role of oxygen free radicals in the initiation, promotion and progression of
carcinogenesis and the protective role of anti-oxidant defenses have been the subject of much
speculation in the recent past with confl icting reports in the literature. Objectives: The aim of this
study was to measure the concentration/levels of serum total proteins, albumin and advanced oxidation
protein products as markers of oxidative stress in sera of patients with an oral pre-cancerous lesion
and frank oral cancer. Materials and methods: The study consisted of sera analysis of 30 new patients
of histologically proven well-differentiated, oral squamous cell carcinoma and 10 patients, clinically
diagnosed with a potentially malignant epithelial lesion, speckled leukoplakia, aged between 40 to
60 years, in addition to 25 healthy controls. One way analyses of variance were used to test the
difference between groups. The normality of data was checked before the statistical analysis was
performed. Results: The study revealed variations in sera levels of albumin and advanced oxidation
protein products to be statistically signifi cant (p < 0.001). Conclusion: The results obtained emphasize
the need for more studies with larger sample sizes to be conducted before a conclusive role could be
drawn in favour of sera levels of total protein, albumin and advanced oxidation protein products as
markers of diagnostic signifi cance and of the transition from the various oral pre-cancerous lesions
and conditions into frank oral cancers.
- Full text:W020151218426769660909.pdf
