Induced pluripotent stem cells in research and therapy
- Author:
Hoon-Koon TEOH
;
Soon-Keng CHEONG
- Publication Type:Review
- Keywords:
embryonic-like properties, regenerative medicine, disease modelling, patient-specific therapy, gene therapy.
- From:The Malaysian Journal of Pathology
2012;34(1):1-13
- CountryMalaysia
- Language:English
-
Abstract:
Induced pluripotent stem cells (iPSC) are derived from human somatic cells through ectopic expression
of transcription factors. This landmark discovery has been considered as a major development towards patient-specifi c iPSC for various biomedical applications. Unlimited self renewal capacity, pluripotency and ease of accessibility to donor tissues contribute to the versatility of iPSC. The
therapeutic potential of iPSC in regenerative medicine, cell-based therapy, disease modelling and
drug discovery is indeed very promising. Continuous progress in iPSC technology provides clearer
understanding of disease pathogenesis and ultimately new optimism in developing treatment or cure for human diseases.
- Full text:W020151218419973888889.pdf
