Cross-reactivity of Malaysian rat cytomegalovirus strains with its human counterpart
- Author:
Camalxaman, S.N.,
;
Zeenathul, N.A.*
;
Quah, Y.W.
;
Loh, H.S.
;
Zuridah, H.
;
Sheikh-Omar, A.R.
;
Mohd-Azmi, M.L.
- Publication Type:Journal Article
- From:Tropical Biomedicine
2011;28(3):661-667
- CountryMalaysia
- Language:English
-
Abstract:
This study probes into the prospect of cross-reactivity of HCMV with RCMV which
has not been acknowledged to date. We describe the uncovering of a protein with an estimated
size of between 61-68 kDa from local RCMV strains which reacted with HCMV positive sera.
Our findings are a first disclosure of a plausible immunological cross-reactivity between
RCMV with its human counterpart which grounds substantial interest implying existence of
conserved determinants between rat and human CMV polypeptides. The cross-reactive protein
most likely represents an enveloped glycoprotein, though the precise identification and its
degree of similarity needs to be evidently defined and further elucidated in forthcoming
experiments.
- Full text:W020150615421631210477.pdf
