Apoptosis changes and SA-beta galactosidase expression in stress-induced premature senescence (SIPS) model of human skin fibroblasts.
- Author:
Abdul Rahim N
;
Makpol S
;
Chua KH
;
Yusof YA
;
Top GM
;
Ngah WZ
- Publication Type:Journal Article
- From:
The Medical Journal of Malaysia
2008;63 Suppl A():71-72
- CountryMalaysia
- Language:Malay
-
Abstract:
Stress-induced premature senescence (SIPS) model is in vitro model of cellular aging. In this study, apoptosis was evaluated in SIPS model and in replicative senescent fibroblasts. We also compared the activity of senescence-associated beta-galactosidase (SA-beta gal) as a biomarker of cellular aging. Our results suggested that SIPS model and senescent fibroblasts might share similar mechanism of aging and apoptosis pathway.
