The effect of vitamin E on basic fibroblast growth factor level in human fibroblast cell culture.
- Author:
Rashid SA
;
Halim AS
;
Muhammad NA
- Publication Type:Journal Article
- From:
The Medical Journal of Malaysia
2008;63 Suppl A():69-70
- CountryMalaysia
- Language:Malay
-
Abstract:
Basic fibroblast growth factor (bFGF) is angiogenic and effective in down-regulating excess collagen production. The aim of this study is to evaluate the effectiveness of vitamin E (Tocotrienol Rich Fraction) in altering the level of bFGF, a cytokine involved in the scar formation process. In this model, normal human fibroblasts were treated with various concentrations of vitamin E at different time frames. The levels of bFGF were determined by Enzyme-Linked Immunosorbant Assay (ELISA). This study demonstrated that Tocotrienol Rich Fraction (TRF) stimulated bFGF production by fibroblast and postulate that vitamin E may decrease aberrant scar formation.
