Scalable production of pancreatic islet progenitors for diabetes cell therapies.
- Author:
Lock LT
;
Tzanakakis ES
- Publication Type:Journal Article
- From:
The Medical Journal of Malaysia
2008;63 Suppl A():5-6
- CountryMalaysia
- Language:Malay
-
Abstract:
Embryonic stem cells (ESCs) can be an inexhaustible source of islet cells for transplantation. Previously published protocols have been characterized by low differentiation efficiency. In this study, we developed a scalable system for the growth and differentiation of hESCs towards pancreatic islets. Our results showed that hESCs can be grown on microcarriers to a larger scale and directed to differentiate into pancreatic progenitor endoderm cells. This culture system would represent an economical differentiation protocol that can be scaled-up to meet the demand in islet transplantation.
