In vivo chromosome aberration test for hydroxyapetite in mice.
- Author:
Kannan TP
;
Nik Ahmad Shah NL
;
Azlina A
;
Samsudin AR
;
Narazah MY
;
Salleh M
- Publication Type:Journal Article
- MeSH:
Bone Marrow Cells/*drug effects;
Bone Substitutes/*toxicity;
*Chromosome Aberrations;
Durapatite/*toxicity;
*Mutagenicity Tests
- From:
The Medical Journal of Malaysia
2004;59 Suppl B():115-116
- CountryMalaysia
- Language:Malay
-
Abstract:
This study evaluates the cytotoxic and mutagenic effect of synthetic hydroxyapatite granules (source: School of Material and Mineral Resources Engineering, Universiti Sains Malaysia) in the bone marrow cells of mice. Mice are exposed to synthetic hydroxyapatite granules, the bone marrow cells are collected and observed for chromosome aberrations. No chromosome aberrations were noticed in the animals exposed to distilled water (negative control) and to the test substance, synthetic hydroxyapatite granules (treatment) groups. Chromosome aberrations were observed in the animals exposed to Mitomycin C (positive control group). There was no indication of cytotoxicity due to synthetic hydroxyapatite granules in the animals as revealed by the mitotic index. Hence, synthetic hydroxyapatite granules are considered non-mutagenic under the prevailing test conditions.
