Autologous human fibrin as the biomaterial for tissue engineering.
- Author:
Ruszymah BH
- Publication Type:Journal Article
- MeSH:
*Biocompatible Materials;
*Bone Transplantation;
Cartilage/*transplantation;
Cell Division/physiology;
Culture Media;
*Fibrin;
Fibroblasts/cytology;
Mesenchymal Stem Cells/cytology;
Mice, Nude;
Organ Culture Techniques;
Periosteum/cytology;
*Skin Transplantation;
*Tissue Engineering
- From:
The Medical Journal of Malaysia
2004;59 Suppl B():30-31
- CountryMalaysia
- Language:Malay
-
Abstract:
Patient own fibrin may act as the safest, cheapest and immediate available biodegradable scaffold material in clinical 1 tissue engineering. This study investigated the feasibility of using patient own fibrin isolated from whole blood to construct a new human cartilage, skin and bone. Constructed in vitro tissues were implanted on the dorsal part of the nude mice for in vivo maturation. After 8 weeks of implantation, the engineered tissues were removed for histological analysis. Our results demonstrated autologous fibrin has great potential as clinical scaffold material to construct various human tissues.
