The effects of autologous human serum on the growth of tissue engineered human articular cartilage.
- Author:
Badrul AH
;
Aminuddin BS
;
Sharaf I
;
Samsudin OC
;
Munirah S
;
Ruszymah BH
- Publication Type:Journal Article
- MeSH:
Cartilage, Articular/growth & development;
Cartilage, Articular/*transplantation;
Cell Count;
Cell Division/physiology;
Chondrocytes/*cytology;
Culture Media;
*Serum;
*Tissue Engineering
- From:
The Medical Journal of Malaysia
2004;59 Suppl B():11-12
- CountryMalaysia
- Language:Malay
-
Abstract:
Culture media supplemented with animal serum e.g. fetal bovine serum; FBS is commonly used for human culture expansion. However, for clinical application, FBS is restricted as its carry a risk of viral or prion transmission. Engineering autologous cartilage with autologous human serum supplementation is seen as a better solution to reduce the risk of transmitting infectious diseases and immune rejection during cartilage transplantation. The purpose of this study is to establish and compare the effects of 10% autologous human serum (AHS) and 10% FBS on the growth of chondrocytes and the formation of tissue engineered human articular cartilage.
